Dimenhydrinate

AHFS Class: 56:22.08 - Antihistamines

Products

Dimenhydrinate is available in 1-mL and 10-mL vials containing dimenhydrinate 50 mg/mL in propylene glycol 50% and water. Sodium hydroxide and/or hydrochloric acid may be used to adjust the pH and benzyl alcohol is present in multiple-dose vials as a preservative. Dimenhydrinate contains 53 to 55.5% of diphenhydramine and 44 to 47% of 8-chlorotheophylline.1(6/06) 4

• pH

From 6.4 to 7.2.1(6/06) 4

Administration

Dimenhydrinate is administered by intramuscular injection or by intravenous injection over two minutes after dilution with 10 mL of sodium chloride 0.9%.1(6/06) 4

Stability

Intact containers should be stored at controlled room temperature and protected from freezing.1(6/06) 4

• pH Effects

A test of dimenhydrinate solutions at pH 2 to 10 showed no separation or precipitation at pH 5.4 to 8.6 on extended room temperature storage. Below pH 5.4, a white powdery precipitate of 8-chlorotheophylline formed within 24 hours. Above pH 8.6, an oily liquid separated within 30 minutes.279

Compatibility

• Solution Compatibility

Dimenhydrinate
Test Soln NameTest Soln MfrBase Drug MfrBase Drug Conc/LRemarksRefsCompat
Dextrose 2.5% in half-strength Ringer's injectionABSE50 mgPhysically compatible3 C
Dextrose 5% in Ringer's injectionABSE50 mgPhysically compatible3 C
Dextrose 5% in half-strength Ringer's injection, lactatedABSE50 mgPhysically compatible3 C
Dextrose 2.5% in Ringer's injection, lactatedABSE50 mgPhysically compatible3 C
Dextrose 5% in Ringer's injection, lactatedABSE50 mgPhysically compatible3 C
Dextrose 10% in Ringer's injection, lactatedABSE50 mgPhysically compatible3 C
Dextrose 2.5% in sodium chloride 0.45%ABSE50 mgPhysically compatible3 C
Dextrose 2.5% in sodium chloride 0.9%ABSE50 mgPhysically compatible3 C
Dextrose 5% in sodium chloride 0.225%ABSE50 mgPhysically compatible3 C
Dextrose 5% in sodium chloride 0.45%ABSE50 mgPhysically compatible3 C
Dextrose 5% in sodium chloride 0.9%ABSE50 mgPhysically compatible3 C
Dextrose 5% in sodium chloride 0.9%SE50 mgPhysically compatible74 C
Dextrose 10% in sodium chloride 0.9%ABSE50 mgPhysically compatible3 C
Dextrose 2.5%ABSE50 mgPhysically compatible3 C
Dextrose 5%ABSE50 mgPhysically compatible3 C
Dextrose 5%SE50 mgPhysically compatible74 C
Dextrose 5%Stable for 10 days at room temperature279 C
Dextrose 10%ABSE50 mgPhysically compatible3 C
Ionosol B in dextrose 5%ABSE50 mgPhysically compatible3 C
Ionosol MB in dextrose 5%ABSE50 mgPhysically compatible3 C
Ringer’s injectionABSE50 mgPhysically compatible3 C
Ringer’s injection, lactatedABSE50 mgPhysically compatible3 C
Ringer’s injection, lactatedSE50 mgPhysically compatible74 C
Sodium chloride 0.45%ABSE50 mgPhysically compatible3 C
Sodium chloride 0.9%ABSE50 mgPhysically compatible3 C
Sodium chloride 0.9%SE50 mgPhysically compatible74 C
Sodium chloride 0.9%Stable for 10 days at room temperature279 C
Sodium lactate 1/6 MABSE50 mgPhysically compatible3 C

• Additive Compatibility

Dimenhydrinate
Test DrugTest Drug MfrTest Drug Conc/LBase Drug MfrBase Drug Conc/LSolutionRemarksRefsCompat
Amikacin sulfateBR5 gSE100 mgD5LR, D5R, D5S, D5W, D10W, LR, NS, R, SLPhysically compatible and both stable for 24 hr at 25 °C294 C
Aminophylline250 mgSE50 mgD5WPhysically compatible74 C
AminophyllineSE1 gSE500 mgD5WPhysically incompatible15 I
Ammonium chlorideAB20 gSE500 mgD5WPhysically compatible15 C
Chloramphenicol sodium succinatePD500 mgSE50 mgD5WPhysically compatible74 C
Heparin sodium12,000 unitsSE50 mgD5WPhysically compatible74 C
Heparin sodiumUP4000 unitsSE500 mgD5WPhysically compatible15 C
Heparin sodiumAB20,000 unitsSE50 mgDPhysically compatible21 C
Hydrocortisone sodium succinateUP100 mgSE50 mgD5WPhysically compatible74 C
Hydrocortisone sodium succinateUP500 mgSE500 mgD5WPhysically incompatible15 I
Hydroxyzine HClRR250 mgSE500 mgD5WPhysically compatible15 C
Norepinephrine bitartrateWI8 mgSE50 mgD5WPhysically compatible74 C
Penicillin G potassium1 million unitsSE50 mgD5WPhysically compatible74 C
Pentobarbital sodiumAB1 gSE500 mgD5WPhysically compatible15 C
Phenobarbital sodiumWI200 mgSE500 mgD5WPhysically compatible15 C
Potassium chloride3 gSE50 mgD5WPhysically compatible74 C
Prochlorperazine edisylateSKF100 mgSE500 mgD5WPhysically compatible15 C
Vancomycin HClLI1 gSE50 mgD5WPhysically compatible74 C

• Drugs in Syringe Compatibility

Dimenhydrinate
Test DrugTest Drug MfrTest Drug ConcBase Drug MfrBase Drug ConcRemarksRefsCompat
Aminophylline50 mg/1 mL10 mg/1 mLLight cloudiness forms immediately2569 I
Ampicillin sodium50 mg/1 mL10 mg/1 mLClear solution2569 C
Atropine sulfateST0.4 mg/1 mLHR50 mg/1 mLPhysically compatible for at least 15 min326 C
Butorphanol tartrateBR4 mg/2 mLHR50 mg/1 mLGas evolves761 I
Caffeine citrate10 mg/1 mL10 mg/1 mLClear solution2569 C
Calcium gluconate100 mg/1 mL10 mg/1 mLClear solution2569 C
Cefazolin sodium100 mg/1 mL10 mg/1 mLClear solution2569 C
Cefotaxime sodium100 mg/1 mL10 mg/1 mLClear solution2569 C
Ceftazidime100 mg/1 mL10 mg/1 mLClear solution2569 C
Cefuroxime sodium100 mg/1 mL10 mg/1 mLClear solution2569 C
Chlorpromazine HClPO50 mg/2 mLHR50 mg/1 mLPhysically incompatible within 15 min326 I
Chlorpromazine HCl25 mg/1 mL10 mg/1 mLClear solution2569 C
Clindamycin phosphate150 mg/1 mL10 mg/1 mLClear solution2569 C
Cloxacillin sodium100 mg/1 mL10 mg/1 mLClear solution2569 C
Cyclosporine50 mg/1 mL10 mg/1 mLClear solution2569 C
Dexamethasone sodium phosphate10 mg/1 mL10 mg/1 mLClear solution2569 C
Diazepam5 mg/1 mL10 mg/1 mLLoss of clarity2569 I
Digoxin0.05 mg/1 mL10 mg/1 mLClear solution2569 C
Diphenhydramine HClPD50 mg/1 mLHR50 mg/1 mLPhysically compatible for at least 15 min326 C
Dobutamine HCl12.5 mg/1 mL10 mg/1 mLClear solution2569 C
DroperidolMN2.5 mg/1 mLHR50 mg/1 mLPhysically compatible for at least 15 min326 C
Fentanyl citrateMN0.05 mg/1 mLHR50 mg/1 mLPhysically compatible for at least 15 min326 C
Furosemide10 mg/1 mL10 mg/1 mLPrecipitate forms2569 I
Gentamicin sulfate10 mg/1 mL10 mg/1 mLClear solution2569 C
Gentamicin sulfate40 mg/1 mL10 mg/1 mLClear solution2569 C
GlycopyrrolateRB0.2 mg/1 mLSE50 mg/1 mLPrecipitates immediately331 I
GlycopyrrolateRB0.2 mg/1 mLSE100 mg/2 mLPrecipitates immediately331 I
GlycopyrrolateRB0.4 mg/2 mLSE50 mg/1 mLPrecipitates immediately331 I
Heparin sodium2500 units/1 mL65 mg/10 mLPhysically compatible for at least 5 min1053 C
Heparin sodium25,000 units/1 mL10 mg/1 mLPrecipitate forms2569 I
Hydrocortisone sodium succinate125 mg/1 mL10 mg/1 mLClear solution2569 C
Hydromorphone HClKN2, 10, 40 mg/1 mLSQ50 mg/1 mLVisually compatible with both drugs stable for 24 hr at 4, 23, and 37 °C. Precipitate forms after 24 hr1776 C
Hydromorphone HCl50 mg/1 mL10 mg/1 mLPrecipitate forms in about 2 hr2569 I
Hydroxyzine HClPF50 mg/1 mLHR50 mg/1 mLPhysically incompatible within 15 min326 I
Iodipamide meglumineSQ52%/40 mLSE50 mg/1 mLForms a precipitate initially but clears within 1 hr and remains clear for 48 hr530 ?
Iodipamide meglumineSQ52%/20 mLSE50 mg/1 mLForms a precipitate initially but clears within 1 hr. Precipitate reforms on standing530 I
Iodipamide meglumineSQ52%/1 mLSE50 mg/1 mLForms a precipitate initially but clears within 1 hr. Precipitate reforms on standing530 I
Iothalamate meglumineMA60%/40 mLSE50 mg/1 mLPhysically compatible for 48 hr530 C
Iothalamate meglumineMA60%/1 mLSE50 mg/1 mLPhysically compatible for 48 hr530 C
Lorazepam4 mg/1 mL10 mg/1 mLClear solution2569 C
Magnesium sulfate500 mg/1 mL10 mg/1 mLClear solution2569 C
Meperidine HClWI50 mg/1 mLHR50 mg/1 mLPhysically compatible for at least 15 min326 C
Metoclopramide HClNO10 mg/2 mLHR50 mg/1 mLPhysically compatible for 15 min at room temperature565 C
Midazolam HClRC5 mg/1 mLSE50 mg/1 mLWhite precipitate forms immediately1145 I
Morphine sulfateST15 mg/1 mLHR50 mg/1 mLPhysically compatible for at least 15 min326 C
Naloxone HCl0.4 mg/1 mL10 mg/1 mLClear solution2569 C
Octreotide acetate0.5 mg/1 mL10 mg/1 mLPrecipitate forms in about 1 hr2569 I
Oxytocin10 units/1 mL10 mg/1 mLPrecipitate forms2569 I
Pantoprazole sodiuma 4 mg/1 mL50 mg/1 mLWhite precipitate2574 I
Penicillin G sodium500,000 units/1 mL10 mg/1 mLClear solution2569 C
Pentazocine lactateWI30 mg/1 mLHR50 mg/1 mLPhysically compatible for at least 15 min326 C
Pentobarbital sodiumAB500 mg/10 mLSE50 mg/1 mLPhysically incompatible55 I
Pentobarbital sodiumAB50 mg/1 mLHR50 mg/1 mLPhysically incompatible within 15 min326 I
Piperacillin sodium–tazobactam sodiuma 200 + 25 mg/1 mL10 mg/1 mLClear solution2569 C
Potassium chloride2 mEq/1 mL10 mg/1 mLPrecipitate forms in about 1 hr2569 I
Prochlorperazine edisylatePO5 mg/1 mLHR50 mg/1 mLPhysically incompatible within 15 min326 I
Promethazine HClPO50 mg/2 mLHR50 mg/1 mLPhysically incompatible within 15 min326 I
Promethazine HCl25 mg/1 mL10 mg/1 mLSolution discolors2569 I
Ranitidine HClGL50 mg/2 mLHR50 mg/1 mLPhysically compatible for 1 hr at 25 °C978 C
Salbutamol1 mg/1 mL10 mg/1 mLPrecipitate forms2569 I
Scopolamine HBrST0.4 mg/1 mLHR50 mg/1 mLPhysically compatible for at least 15 min326 C
Sodium bicarbonate1 mEq/1 mL10 mg/1 mLPrecipitates immediately2569 I
Tobramycin sulfate40 mg/1 mL10 mg/1 mLClear solution2569 C
Trimethoprim–sulfamethoxazole16 + 80 mg/1 mL10 mg/1 mLClear solution2569 C
Vancomycin HCl50 mg/1 mL10 mg/1 mLPrecipitate forms2569 I
Verapamil HCl2.5 mg/1 mL10 mg/1 mLClear solution2569 C
a Test performed using the formulation WITHOUT edetate disodium.

• Y-Site Injection Compatibility (1:1 Mixture)

Dimenhydrinate
Test DrugTest Drug MfrTest Drug ConcBase Drug MfrBase Drug ConcRemarksRefsCompat
Acyclovir sodiumBW5 mg/mLa SE1 mg/mLa Physically compatible for 4 hr at 25 °C1157 C
Ciprofloxacin2 mg/mL10 mg/mLClear solution2569 C
Fluconazole2 mg/mL10 mg/mLClear solution2569 C
Hydroxyethyl starch 130/0.4 in sodium chloride 0.9%FRK6%SZ0.5, 0.75, 1 mg/mLa Visually compatible for 24 hr at room temperature2770 C
Metronidazole5 mg/mL10 mg/mLClear solution2569 C
Pantoprazole sodiumALTc 0.16 to 0.8 mg/mLb AST0.5 to 1 mg/mLa Visually compatible for 12 hr at 23 °C2603 C
a Tested in dextrose 5%.
b Tested in sodium chloride 0.9%.
c Test performed using the formulation WITHOUT edetate disodium.
Handbook on Injectable Drugs. © Copyright, 1977-2014. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.
Original Publication Date: October 1, 1982.
Selected Revisions: January 24, 2014.
ASHP

References

For a list of references cited in the text of this monograph, search the monograph titled HID references.